1613168-86-7

Basic information

• Product Name: 3-(2-fluoro4-{1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]propanamide
• Synonyms: 3-(2-fluoro4-{1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]propanamide
• CAS NO: 1613168-86-7
• Molecular Weight: 526.537
• Mol File: 1613168-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-fluoro4-{1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-fluoro4-{1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]propanamide(1613168-86-7)
• EPA Substance Registry System: 3-(2-fluoro4-{1H-pyrazolo[3,4-b]pyridin-5-yl}phenyl)-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]propanamide(1613168-86-7)

Safety Data

• Hazardous Substances Data: 1613168-86-7(Hazardous Substances Data)

Upstream product

• 1093819-50-1 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine 
• 1613169-14-4 tert-butyl 4-({4-[3-(4-bromo-2-fluorophenyl)propanamido]-2-(trifluoromethyl)phenyl}methyl)piperazine-1-carboxylate 

Relevant articles and documents

COMPOUNDS INCLUDING MAP KINASE INTERACTING KINASES 1 AND 2 (MNK1 AND MNK2) MODULATORS AND ABL AND ABL (T315I) INHIBITORS, AND USES THEREOF

The present invention relates to certain piperazine-based compounds that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b and/or as ABL or ABL (T315I) inhibitors. The invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of cancer, inflammatory and Alzheimer disease conditions, as well as methods of treatment of these disorders.