1613231-72-3Relevant academic research and scientific papers
Enantioselective Synthesis of Bicyclopentane-Containing Alcohols via Asymmetric Transfer Hydrogenation
Vyas, Vijyesh K.,Clarkson, Guy J.,Wills, Martin
, p. 3179 - 3183 (2021/05/04)
Compounds a containing bicyclo[1.1.1]pentane (BCP) adjacent to a chiral center can be prepared with high enantiomeric excess through asymmetric transfer hydrogenation (ATH) of adjacent ketones. In the reduction step, the BCP occupies the position distant from the η6-arene of the catalyst. The reduction was applied to the synthesis of a BCP analogue of the antihistamine drug neobenodine.
Synthesis of highly substituted 3-formylfurans by a gold(I)-catalyzed oxidation/1,2-alkynyl migration/cyclization cascade
Wang, Tao,Shi, Shuai,Hansmann, Max M.,Rettenmeier, Eva,Rudolph, Matthias,Hashmi, A. Stephen K.
supporting information, p. 3715 - 3719 (2014/04/17)
3-Formylfuran derivatives are core structures of a variety of bioactive natural products. However, procedures for their preparation are still rare and generally inefficient in terms of atom economy: These methods require multiple steps or harsh reaction c
