1613245-75-2Relevant academic research and scientific papers
Transition-metal-assisted radical/radical cross-coupling: A new strategy to the oxidative C(sp3)-H/N-H cross-coupling
Zhou, Liangliang,Tang, Shan,Qi, Xiaotian,Lin, Caitao,Liu, Kun,Liu, Chao,Lan, Yu,Lei, Aiwen
, p. 3404 - 3407 (2014)
A transition-metal-assisted oxidative C(sp3)-H/N-H cross-coupling reaction of N-alkoxyamides with aliphatic hydrocarbons is described. During the reaction, nitrogen radicals were generated from the oxidation of N-alkoxyamides. Experiments and DFT calculations revealed that transition-metal catalyst could lower the reactivity of the generated nitrogen radical by the coordination of the transition metal, which allowed the selective radical/radical cross-coupling with the transient sp3 carbon radical to construct C(sp3) - N bonds. Various C(sp3)-H bonds could be transformed into C(sp3)-N bonds through this radical amidation strategy.
