1613252-38-2Relevant academic research and scientific papers
Copper- and palladium-cocatalyzed intramolecular C-H functionalization/C-N bond formation: A route to the synthesis of indoloisoquinoline derivatives
Hazra, Somjit,Mondal, Biplab,Rahaman, Habibur,Roy, Brindaban
supporting information, p. 2806 - 2812 (2014/05/06)
A Cu and Pd bi-catalytic system is found to be very effective for the indole C2-H functionalization/C-N bond formation process.This is a unique reaction in which isoquinoline systems were synthesized from aldoximes rather than from ketoximes. During the reaction Cu(OTf)2 converts the aldoximes into the corresponding cyanides and indoloisoquinolines, but introduction of Pd(OAc)2 changes the outcome of the reaction significantly, by suppressing the formation of cyano products, thus giving exclusively indoloisoquinolines. A range of substituted indoloisoquinolines and aza-indoloisoquinolines are prepared in good to very good yields under air. A new approach to the synthesis of indoloisoquinoline derivatives is described. The activation of the indole C2-H bond is accomplished here by using a Pd(OAc)2 and Cu(OTf)2 bi-catalytic system. In this reaction aldoximes are converted into the corresponding isoquinolines in open atmosphere under mild reaction condition. Copyright
