1613267-29-0

Basic information

• Product Name: N-amino-3-[(1H-pyrrol-1-yl)methyl]pyridinium mesitylenesulfonate
• Synonyms: N-amino-3-[(1H-pyrrol-1-yl)methyl]pyridinium mesitylenesulfonate
• CAS NO: 1613267-29-0
• Molecular Weight: 373.476
• Mol File: 1613267-29-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-amino-3-[(1H-pyrrol-1-yl)methyl]pyridinium mesitylenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: N-amino-3-[(1H-pyrrol-1-yl)methyl]pyridinium mesitylenesulfonate(1613267-29-0)
• EPA Substance Registry System: N-amino-3-[(1H-pyrrol-1-yl)methyl]pyridinium mesitylenesulfonate(1613267-29-0)

Safety Data

• Hazardous Substances Data: 1613267-29-0(Hazardous Substances Data)

Upstream product

• 36016-40-7 mesitylenesulfonylhydroxylamine 
• 80866-95-1 3-((1H-pyrrol-1-yl)methyl)pyridine 

Downstream Products

• 1613267-16-5 1-(benzoylimino)-3-(1H-pyrrol-1-ylmethyl)-pyridinium ylide 
• 1613267-17-6 1-[(4-methylbenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-18-7 1-[(4-ethylbenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-19-8 1-[(4-methoxybenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-20-1 1-[(4-butylbenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-22-3 1-[(4-chlorobenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-23-4 1-[(4-bromobenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-21-2 1-[(4-fluorobenzoyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-24-5 1-[(phenylsulfonyl)imino]-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-25-6 1-([(4-methylphenyl)sulfonyl]imino)-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-26-7 1-([(4-methoxyphenyl)sulfonyl]imino)-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 
• 1613267-27-8 1-(([3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl)imino)-3-(1H-pyrrol-1-ylmethyl)pyridinium ylide 

Relevant articles and documents

Synthesis and biological evaluation of substituted N-[3-(1H-pyrrol-1-yl) methyl]-1,2,5,6-tetrahydropyridin-1-yl]benzamide/benzene Sulfonamides as anti-inflammatory agents

The pharmacological activities of tetrahydropyridine (THP) derivatives are dependent on the substituent ring moiety. In this study, we investigate the anti-inflammatory activities of 12 newly synthesized substituted N-[3-(1H-pyrrol-1-yl)methyl]-1,2,5,6-tetrahydrobenzamide/benzene sulfonamides (9a-l) in murine BV-2 microglial cells. All compounds were initially screened for attenuation of nitric oxide (NO) production in lipopolysaccharide (LPS) (1 μg/mL)-activated microglial cells. The data show that only SO 2-substituted THPs were effective at sub-lethal concentrations (IC50 values of 12.92 μM (9i), 14.64 μM (9j), 19.63 μM (9k)) relative to L-N6-(1-iminoethyl)lysine positive control (IC50 = 3.1 μM). The most potent SO2-substituted compound (9i) also blocked the LPS-inducible nitric oxide synthase (iNOS) and attenuated the release of several cytokines including IL-1α, IL-10, and IL-6. These findings establish the moderate immuno-modulating effects of SO2-substituted THP derivatives.