16133-44-1

Upstream product

• 27691-52-7 S,S-dimethyl-N-(p-nitrophenyl)sulfilimine 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 82633-22-5 methyl 2-[(4-nitrophenyl)amino]-2-oxoacetate 
• 16133-46-3 methyl 1,4-dihydro-6-nitro-4-oxo-2-quinolinecarboxylate 
• 52980-10-6 6-amino-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid 
• 52979-42-7 methyl 6-amino-1,4-dihydro-4-oxo-2-quinolinecarboxylate 
• 169831-71-4 methyl 1,4-dihydro-6-<(4-methylbenzoyl)amino>-4-oxo-2-quinolinecarboxylate 
• 169831-77-0 methyl 4-methoxy-6-<(4-methylbenzoyl)amino>-2-quinolinecarboxylate 
• 169831-74-7 methyl 1,4-dihydro-1-methyl-6-<(4-methylbenzoyl)amino>-4-oxo-2-quinolinecarboxylate 
• 1395241-49-2 dimethyl 6'-amino-5'-cyano-5-methyl-1'-p-nitrophenylspiro[indoline-3,4'-pyridine]-2',3'-dicarboxylate 

Relevant academic research and scientific papers

Novel One-Pot Synthesis of Functionalized Quinolines from Isocyanides, Aniline, and Acetylene Dicarboxylate via Cu-Catalyzed Intramolecular C─H Activation Reactions

The one-pot synthesis of a novel class of substituted quinoline derivatives with good yields is achieved via the Cu-catalyzed intramolecular C─H activation reaction between isocyanides, aniline, and acetylene dicarboxylate in MeCN at room temperature. The

Novel vitexin-inspired scaffold against leukemia

Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. Up to a quarter of ALL patients relapse and face poor prognosis. To identify new compound leads, we conducted a phenotypic screen using terrestrial natural product (NP) fr

CuCl2-mediated reaction of [60]fullerene with amines in the presence or absence of dimethyl acetylenedicarboxylate: Preparation of fulleropyrroline or aziridinofullerene derivatives

The CuCl2-mediated three-component reaction of C60 with amines and dimethyl acetylenedicarboxylate afforded the fulleropyrrolines in moderate yields. Furthermore, the CuCl2-mediated oxidative [2 + 1] reaction of C60 with aromatic amines bearing a strong electron-withdrawing group provided the aziridinofullerenes and the selective cis-1-bisaziridinofullerenes.

Efficient synthesis of the functionalized spiro[indoline-3,4'-pyridine] via four-component reaction

An efficient synthetic procedure for the functionalized spiro[indoline-3,4'-pyridine] was developed via the four-component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages

Amide derivatives and nociceptin antagonists

The present invention relates to a compound of the formula [1′] wherein R2is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.

A synthesis of 4-quinolone-3-carboxylic acids via pyrolysis of N- aryldioxopyrrolines

A synthesis of 4-quinolone-3-carboxylic acids (8) was achieved by pyrolysis of 4,5-dimethoxycarbonyl-1-aryl-1H-pyrrole-2,3-diones (3) followed by selective demethoxycarbonylation of the resulting 2,3-dimethoxycarbonyl-4- quinolones (4) in excellent overall yields.

Kynurenic acid derivatives inhibit the binding of nerve growth factor (NGF) to the low-affinity p75 NGF receptor

The ability of a series of substituted kynurenic acids, thienopyridinonecarboxylic acids, and related compounds to inhibit the binding of nerve growth factor (NGF) to the p75 NGF receptor (NGFR) was evaluated in a radioligand binding assay that utilized a

Oxidation of Enamine-esters with Lead Tetra-acetate. Part 2. Products from N-Aryl- and N-Benzyl-aminofumarates.

Dimethyl anilinofumarate and N-benzylaminofumarate are oxidised by lead tetra-acetate to pyrroline, pyrrolin-2-one and pyrrole derivatives.Some other N-arylaminofumarates give the corresponding oxanilates by autoxidative cleavage.