1613303-22-2Relevant academic research and scientific papers
Copper-catalyzed radical cyclization to access 3-hydroxypyrroloindoline: Biomimetic synthesis of protubonine A
Deng, Xu,Liang, Kangjiang,Tong, Xiaogang,Ding, Ming,Li, Dashan,Xia, Chengfeng
, p. 3276 - 3279 (2014)
An unprecedented copper-catalyzed intramolecular radical cyclization was developed for the synthesis of 3-hydroxypyrroloindoline skeletons in excellent yields. The 3-hydroxyl group was introduced by trapping the radical intermediate with molecular oxygen or TEMPO. This process represents a unique radical oxidation pathway for tryptamine/tryptophan derivatives and allows a rapid biomimetic synthesis of natural product protubonine A.
