1613336-69-8

Basic information

• Product Name: N-(4-(2-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide
• CAS NO: 1613336-69-8
• Molecular Weight: 591.571
• Mol File: 1613336-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-(2-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(2-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide(1613336-69-8)
• EPA Substance Registry System: N-(4-(2-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide(1613336-69-8)

Safety Data

• Hazardous Substances Data: 1613336-69-8(Hazardous Substances Data)

Upstream product

• 133-91-5 3,5-diiodosalicylic acid 
• 56705-85-2 4-(2-chlorophenoxy)aniline 
• 42016-91-1 2-hydroxy-3,5-diiodobenzoyl chloride 

Relevant articles and documents

Dual protonophore-chitinase inhibitors dramatically affect O. Volvulus molting

The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closantel is also a known protonophore, we performed a simple scaffold modulation to map out the structural features that are relevant for its individual or dual biochemical roles. Furthermore, we present that either OvCHT1 inhibition or protonophoric activity was capable of affecting O. volvulus L3 molting and that the presence of both activities in a single molecule yielded more potent inhibition of the nematode's developmental process.