1613396-59-0

Upstream product

• 1191094-90-2 methyl 2-(cyclobutanecarbonyl)-3-(dimethylamino)acrylate 
• 137638-05-2 methyl 3-cyclobutyl-3-oxo-propanoate 
• 5006-22-4 Cyclobutanecarbonyl chloride 
• 1613396-57-8 methyl 1-(4-chlorophenyl)-5-cyclobutyl-pyrazole-4-carboxylate 

Downstream Products

• 1613395-33-7 1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one 
• 1613396-61-4 1-(4-chlorophenyl)-5-cylocbutyl-pyrazol-4-amine 
• 1616384-56-5 (2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide 

Relevant academic research and scientific papers

DIAZOLE AMIDES

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated

DIAZOLE LACTAMS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.