1613397-63-9Relevant academic research and scientific papers
Design and synthesis of 24-fluorinated bafilomycin analogue as an NMR probe with potent inhibitory activity to vacuolar-type ATPase
Shibata, Hajime,Tsuchikawa, Hiroshi,Matsumori, Nobuaki,Murata, Michio,Usui, Takeo
, p. 474 - 476 (2014)
A fluorine-labeled bafilomycin analogue was designed and convergently synthesized from three segments via the Stille coupling, macrolactonization, and diastereoselective aldol reaction. The V-ATPase inhibitory activity of the analogue was comparable to that of the natural product, indicating its utility as a potential molecular probe for investigating the inhibition mechanism of bafilomycin by NMR.
