1613402-41-7Relevant academic research and scientific papers
Ionic liquid 1-ethyl-3-methylimidazolium acetate: An attractive solvent for native chemical ligation of peptides
Kühl, Toni,Chen, Ming,Teichmann, Kathleen,Stark, Annegret,Imhof, Diana
, p. 3658 - 3662 (2014/06/23)
The ionic liquid 1-ethyl-3-methylimidazolium acetate ([C 2mim][OAc]) was successfully used as alternative solvent for native chemical ligation of peptide fragments to produce model peptide LYRAXCRANK (X = G, A, L, N, Q, K, and F). The commonly used buffer system including thiol additives such as thiophenol and benzyl mercaptan can be replaced by the nontoxic ionic liquid [C2mim][OAc]. In addition to improving the solubility of the peptides in [C2mim][OAc], yields and rates of the ligation reactions were found to be efficiently enhanced.
