1613407-00-3Relevant academic research and scientific papers
Merging gold and organocatalysis: A facile asymmetric synthesis of annulated pyrroles
Hack, Daniel,Loh, Charles C. J.,Hartmann, Jan M.,Raabe, Gerhard,Enders, Dieter
supporting information, p. 3917 - 3921 (2014/04/17)
The combination of cinchona-alkaloid-derived primary amine and Au I-phosphine catalysts allowed the selective C-H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities. Outwitted: The combination of cinchona-alkaloid-derived primary amine and Au I-phosphine catalysts allowed the selective C-H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities (see scheme).
