1613512-89-2

Basic information

• Product Name: 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate
• Synonyms: 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate
• CAS NO: 1613512-89-2
• Molecular Weight: 345.269
• Mol File: 1613512-89-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate(1613512-89-2)
• EPA Substance Registry System: 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate(1613512-89-2)

Safety Data

• Hazardous Substances Data: 1613512-89-2(Hazardous Substances Data)

Upstream product

• 1613512-88-1 3,5-dichlorobenzyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)ethyl)piperidine-1-carboxylate 
• 1613512-87-0 3,5-dichlorobenzyl 4-(2-((tert-butoxycarbonyl)amino)ethyl)piperidine-1-carboxylate 
• 1175526-48-3 3,5-dichlorobenzyl carbonochloridate 
• 165528-81-4 tert-butyl 2-(piperidin-4-yl)ethylcarbamate 

Downstream Products

• 1613513-36-2 3,5-dichlorobenzyl 4-(2-(N-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-carboxamido)ethyl)piperidine-1-carboxylate 

Relevant articles and documents

Development of autotaxin inhibitors: A series of zinc binding triazoles

A series of inhibitors of Autotaxin (ATX) has been developed using the binding mode of known inhibitor, PF-8380, as a template. Replacement of the benzoxazolone with a triazole zinc-binding motif reduced crystallinity and improved solubility relative to PF-8380. Modification of the linker region removed hERG activity and led to compound 12 – a selective, high affinity, orally-bioavailable inhibitor of ATX. Compound 12 concentration-dependently inhibits autotaxin and formation of LPA in vivo, as shown in pharmacokinetic-pharmacodynamic experiments.