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161356-05-4

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161356-05-4 Usage

Description

4-Hydroxy-N-Phenylbenzene Sulphonamide (often abbreviated as 4-HPS) is an organic compound characterized by its off-white solid appearance. It features a unique structure that includes a hydroxyl group (-OH), a benzene ring, a sulphonic acid, and an attached N-phenyl group. This composition enables it to interact distinctively with other compounds, making it a versatile chemical with a range of applications.

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-N-Phenylbenzene Sulphonamide is used as a key component in the synthesis of various drugs. Its chemical structure allows it to react with other compounds, facilitating the creation of new pharmaceutical products.
Used in Chemical Research:
4-HPS is employed as a research compound in the field of chemistry, where its distinctive reactivity and interactions with other substances are studied. This research can lead to the development of new chemical processes and applications.
Used in Material Science:
In the realm of material science, 4-Hydroxy-N-Phenylbenzene Sulphonamide is used as a building block for the development of new materials. Its unique structure contributes to the properties of these materials, potentially leading to advancements in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 161356-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,3,5 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 161356-05:
(8*1)+(7*6)+(6*1)+(5*3)+(4*5)+(3*6)+(2*0)+(1*5)=114
114 % 10 = 4
So 161356-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO3S/c14-11-6-8-12(9-7-11)17(15,16)13-10-4-2-1-3-5-10/h1-9,13-14H

161356-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-hydroxy-N-phenylbenzenesulfonamide

1.2 Other means of identification

Product number -
Other names N-phenyl-4-hydroxybenzenesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:161356-05-4 SDS

161356-05-4Downstream Products

161356-05-4Relevant articles and documents

Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors

Li, Ya-Li,Qi, Xiang-Yu,Jiang, Hui,Deng, Xiao-Dong,Dong, Yan-Ping,Ding, Ting-Bo,Zhou, Lu,Men, Peng,Chu, Yong,Wang, Ren-Xiao,Jiang, Xian-Cheng,Ye, De-Yong

, p. 6173 - 6184 (2015/09/15)

Sphingomyelin synthase (SMS) has been proved to be a potential drug target for the treatment of atherosclerosis. However, few SMS inhibitors have been reported. In this paper, structure-based virtual screening was performed on hSMS1. SAPA 1a was discovered as a novel SMS1 inhibitor with an IC50 value of 5.2 μM in enzymatic assay. A series of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) were synthesized and their biological activities toward SMS1 were evaluated. Among them, SAPA 1j was found to be the most potent SMS1 inhibitor with an IC50 value of 2.1 μM in in vitro assay. The molecular docking studies suggested the interaction modes of SMS1 inhibitors and PC with the active site of SMS1. Site-directed mutagenesis validated the involvement of residues Arg342 and Tyr338 in enzymatic sphingomyelin production. The discovery of SAPA derivatives as a novel class of SMS1 inhibitors would advance the development of more effective SMS1 inhibitors.

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