161356-05-4

Basic information

• Product Name: 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE
• Synonyms: 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE;N-(Phenyl)-1-phenol-4-sulfonamide;4-HYDOXY-N-PHENYLBENZENESULPHONAMIDE;4-HYDROXY-N-PHENYLBE;4-Hydroxybenzensulfone Anilide;4-Hydroxy-N-phenylbenzenesulfonamide
• CAS NO: 161356-05-4
• Molecular Formula: C₁₂H₁₁NO₃S
• Molecular Weight: 249.29
• Mol File: 161356-05-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 135-137 °C
• Boiling Point: 440.638 °C at 760 mmHg
• Flash Point: 220.29 °C
• Appearance: /
• Density: 1.409 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 7.67±0.15(Predicted)
• CAS DataBase Reference: 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE(161356-05-4)
• EPA Substance Registry System: 4-HYDROXY-N-PHENYLBENZENE SULPHONAMIDE(161356-05-4)

Safety Data

• Hazardous Substances Data: 161356-05-4(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-N-Phenylbenzene Sulphonamide (often abbreviated as 4-HPS) is a chemical compound known for its many applications in different industries. As an organic compound, it typically appears as an off-white coloured solid. From an application standpoint, it's widely utilized in the pharmaceutical sector for the production of various drugs. Its structure, composed of hydroxyl group (-OH), benzene ring, sulphonic acid, and an attached N-phenyl group, allows it to react in distinctive ways with other compounds, leading to varied usages. Like any other chemical compound, it needs to be adequately handled and stored to prevent adverse reactions or hazards.

InChI:InChI=1/C12H11NO3S/c14-11-6-8-12(9-7-11)17(15,16)13-10-4-2-1-3-5-10/h1-9,13-14H

Upstream product

• 861541-55-1 4-ethoxycarbonyloxy-benzenesulfonic acid anilide 
• 4025-67-6 4-hydroxybenzene-1-sulfonyl chloride 
• 62-53-3 aniline 
• 825-90-1 sodium p-hydroxybenzenesulfonate 

Relevant articles and documents

Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors

Sphingomyelin synthase (SMS) has been proved to be a potential drug target for the treatment of atherosclerosis. However, few SMS inhibitors have been reported. In this paper, structure-based virtual screening was performed on hSMS1. SAPA 1a was discovered as a novel SMS1 inhibitor with an IC50 value of 5.2 μM in enzymatic assay. A series of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) were synthesized and their biological activities toward SMS1 were evaluated. Among them, SAPA 1j was found to be the most potent SMS1 inhibitor with an IC50 value of 2.1 μM in in vitro assay. The molecular docking studies suggested the interaction modes of SMS1 inhibitors and PC with the active site of SMS1. Site-directed mutagenesis validated the involvement of residues Arg342 and Tyr338 in enzymatic sphingomyelin production. The discovery of SAPA derivatives as a novel class of SMS1 inhibitors would advance the development of more effective SMS1 inhibitors.