1613703-53-9Relevant academic research and scientific papers
INSULIN DERIVATIVES FOR DIABETES TREATMENT
-
Page/Page column 47, (2014/07/07)
Compounds, compositions, and methods for smart delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
