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ARN-3236 is a novel, potent, and selective small molecule inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the de novo pyrimidine synthesis pathway. This chemical has shown potential as a therapeutic agent for the treatment of various diseases, including autoimmune disorders and cancer, by modulating the immune response and inhibiting the proliferation of rapidly dividing cells. The selective inhibition of DHODH by ARN-3236 leads to the disruption of pyrimidine synthesis, ultimately affecting the cellular processes that rely on this pathway, making it a promising candidate for further research and development in the field of medicine.

1613710-01-2

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1613710-01-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1613710-01-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,3,7,1 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1613710-01:
(9*1)+(8*6)+(7*1)+(6*3)+(5*7)+(4*1)+(3*0)+(2*0)+(1*1)=122
122 % 10 = 2
So 1613710-01-2 is a valid CAS Registry Number.

1613710-01-2Downstream Products

1613710-01-2Relevant academic research and scientific papers

SUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINE AND 1H-PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS SALT INDUCIBLE KINASE 2 (SIK2) INHIBITORS

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Paragraph 00207, (2014/07/07)

The present invention relates to compounds according to Formulas I, IA or IB: to pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

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