1613726-67-2Relevant academic research and scientific papers
Synthesis, characterization, and antimycobacterial activity of novel thymol-triazole hybrids
Negi, Beena,Rawat, Diwan S
, p. 113 - 124 (2018/09/14)
Thymol is a naturally occurring phenolic compound showing various biological activities. A library of novel thymol-triazole hybrids was synthesized and evaluated for their inhibitory activity against Mycobacterium tuberculosis (M.tb), the causative agent of TB. Most of the compounds were found to be active against M.tb H37Rv at 50 μg/mL concentration. These identified compounds have promise to be further optimized into more potent inhibitors against M.tb.
Synthesis of novel 1,2,3-triazole derivatives of isoniazid and their in vitro and in vivo antimycobacterial activity evaluation
Kumar, Deepak,Beena,Khare, Garima,Kidwai, Saqib,Tyagi, Anil K.,Singh, Ramandeep,Rawat, Diwan S.
, p. 301 - 313 (2014/06/09)
We report herein the synthesis and antimycobacterial activity of 1,2,3-triazole derivatives of isoniazid. Most of the compounds exhibited potent activity against Mycobacterium tuberculosis H37Rv strain with MIC99 values ranging from 0.195 to 1.
