161398-29-4Relevant academic research and scientific papers
2-IMIDAZOLES
-
Page/Page column 8-9, (2008/12/06)
The present invention relates to compounds of formula I, wherein X is —CH2— or —NH—;Y is —CH(lower alkoxy)-, —CH(lower alkyl)-, —O—, —S—, —S(O)—, —S(O)2— or —CH2—; andAr is phenyl or naphthyl, which rings are optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkoxy, lower alkyl and lower alkyl substituted by halogen;or a pharmaceutically-acceptable acid-addition salt thereof;with the proviso that, when X is —NH—, Y is —CH(lower alkyl)- or —CH2—;and the further proviso that the compound is not2-phenethyl-1H-imidazole hydrochloride,2-(3,4-dichloro-phenoxymethyl)-1H-imidazole hydrochloride,2-(2-chloro-phenoxymethyl)-1H-imidazole hydrochloride,2-(2,3-dichloro-phenoxymethyl)-1H-imidazole,benzyl-(1H-imidazol-2-yl)-amine,(4-chloro-benzyl)-(1H-imidazol-2-yl)-amine, or(2-chloro-benzyl)-(1H-imidazol-2-yl)-amine. The invention relates also to a pharmaceutically-acceptable acid-addition salt of such a compound, processes for making the compound, and a composition comprising such a compound.
Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
-
, (2008/06/13)
A novel propenoic acid derivative which exhibits adenosine A1 antagonism is defined by the general formula (I): STR1 (wherein A represents an aromatic ring; R1 represents aryl or the like; R2, R3 and R4 each represent hydrogen, lower alkyl or the like; and R7 and R8 each represent lower alkyl or the like) or a pharmacologically acceptable salt thereof.
