161398-79-4Relevant academic research and scientific papers
Anthranilamide inhibitors of factor Xa
Mendel, David,Marquart, Angela L.,Joseph, Sajan,Waid, Philip,Yee, Ying K.,Tebbe, Anne Louise,Ratz, Andrew M.,Herron, David K.,Goodson, Theodore,Masters, John J.,Franciskovich, Jeffry B.,Tinsley, Jennifer M.,Wiley, Michael R.,Weir, Leonard C.,Kyle, Jeffrey A.,Klimkowski, Valentine J.,Smith, Gerald F.,Towner, Richard D.,Froelich, Larry L.,Buben, John,Craft, Trelia J.
, p. 4832 - 4836 (2008/02/11)
SAR about the B-ring of a series of N2-aroyl anthranilamide factor Xa (fXa) inhibitors is described. B-ring o-aminoalkylether and B-ring p-amine probes of the S1′ and S4 sites, respectively, afforded picomolar fXa inhibitors that performed well in in vitro anticoagulation assays.
ANTITHROMBOTIC DIAMIDES
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Page/Page column 29-30, (2008/06/13)
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
ANTITHROMBOTIC AROMATIC ETHERS
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Page/Page column 52, (2008/06/13)
This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives
Million,Boiziau,Parker,Tocque,Roques,Garbay
, p. 4693 - 4703 (2007/10/03)
Several series of hydroxybiphenyl compounds substituted by a hydrophobic group (tert-butyl or phenyl) and bearing a free or protected carboxylic moiety were synthesized. The compounds were tested for their ability to inhibit the intrinsic tyrosine protein
