1614-33-1

Basic information

• Product Name: N-(4-THIOUREIDO-PHENYL)-ACETAMIDE
• Synonyms: N-(4-THIOUREIDO-PHENYL)-ACETAMIDE;N-[4-(carbamothioylamino)phenyl]acetamide
• CAS NO: 1614-33-1
• Molecular Formula: C₉H₁₁N₃OS
• Molecular Weight: 209.27
• Mol File: 1614-33-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-THIOUREIDO-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-THIOUREIDO-PHENYL)-ACETAMIDE(1614-33-1)
• EPA Substance Registry System: N-(4-THIOUREIDO-PHENYL)-ACETAMIDE(1614-33-1)

Safety Data

• Hazardous Substances Data: 1614-33-1(Hazardous Substances Data)

Usage

General Description

N-(4-thioureido-phenyl)-acetamide, also known as PTU (propylthiouracil), is a chemical compound with the molecular formula C9H10N2OS. It is an antithyroid drug and is used to treat hyperthyroidism by inhibiting the production of thyroid hormones. PTU works by blocking iodine organification and inhibiting the thyroid peroxidase enzyme, which are essential for the synthesis of thyroid hormones. The compound has a thiourea structure, which gives it its antithyroid properties. It is commonly used in the treatment of Graves' disease and other thyroid disorders. PTU may also have other pharmacological effects, such as anti-inflammatory and immunosuppressive properties. However, it can have side effects and should be used with caution under medical supervision.

Upstream product

• 769121-30-4 (4-acetylaminophenyl)carbamic acid tert-butyl ester 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 96938-56-6 N-((4-acetamidophenyl)carbamothioyl)benzamide 
• 106-50-3 1,4-phenylenediamine 
• 100-01-6 4-nitro-aniline 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 35008-62-9 4-(N-acetylamino)phenyl isothiocyanate 

Downstream Products

• 1619-43-8 N-(4-((4-phenylthiazol-2-yl)amino)phenyl)acetamide 
• 339231-67-3 N-(4-((4-(3,4-dichlorophenyl)thiazol-2-yl)amino)phenyl)acetamide 
• 339231-43-5 N-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)acetamide 

Relevant articles and documents

Thiazole ring-containing amide compounds as well as preparation method and application thereof

The invention discloses thiazole ring-containing amide compounds as well as a preparation method and application thereof, and belongs to the field of chemical technologies and pesticides. According to the present invention, p-phenylenediamine is adopted as a raw material to synthesize a series of the thiazole ring-containing amide compounds, and the synthesized thiazole ring-containing amide compounds have good inhibition effects on Xanthomonas oryzae pv.Oryza (Xoo), Xanthomonas oryzae pv.Oryzcola (Xoc) and Xanthomonas axonophora pv.Citri (Xac) in agricultural diseases and insect pests, and can be used for preparing the anti-plant bacterium agent.

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against: Klebsiella pneumoniae

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).