1614-33-1

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-THIOUREIDO-PHENYL)-ACETAMIDE is used as an antithyroid drug for the treatment of hyperthyroidism. It functions by blocking iodine organification and inhibiting the thyroid peroxidase enzyme, which are vital for the synthesis of thyroid hormones. This action helps in managing the symptoms and complications associated with hyperthyroidism.
Used in Treatment of Graves' Disease:
In the medical field, N-(4-THIOUREIDO-PHENYL)-ACETAMIDE is used as a therapeutic agent for Graves' disease, an autoimmune disorder that leads to overproduction of thyroid hormones. PTU helps in controlling the disease by reducing the hormone levels and alleviating the associated symptoms.
Used in Other Thyroid Disorders:
N-(4-THIOUREIDO-PHENYL)-ACETAMIDE is also utilized in the management of other thyroid disorders characterized by excessive thyroid hormone production. Its ability to inhibit key enzymes in hormone synthesis makes it a valuable tool in the treatment of such conditions.
While PTU has significant therapeutic applications, it may also possess anti-inflammatory and immunosuppressive properties, which could potentially expand its use in other areas of medicine. However, due to possible side effects, it should be used with caution and under medical supervision.

Upstream product

• 35008-62-9 4-(N-acetylamino)phenyl isothiocyanate 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 100-01-6 4-nitro-aniline 
• 106-50-3 1,4-phenylenediamine 
• 96938-56-6 N-((4-acetamidophenyl)carbamothioyl)benzamide 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 769121-30-4 (4-acetylaminophenyl)carbamic acid tert-butyl ester 

Downstream Products

• 1619-43-8 N-(4-((4-phenylthiazol-2-yl)amino)phenyl)acetamide 
• 339231-67-3 N-(4-((4-(3,4-dichlorophenyl)thiazol-2-yl)amino)phenyl)acetamide 
• 339231-43-5 N-(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenyl)acetamide 

Relevant academic research and scientific papers

Thiazole ring-containing amide compounds as well as preparation method and application thereof

The invention discloses thiazole ring-containing amide compounds as well as a preparation method and application thereof, and belongs to the field of chemical technologies and pesticides. According to the present invention, p-phenylenediamine is adopted as a raw material to synthesize a series of the thiazole ring-containing amide compounds, and the synthesized thiazole ring-containing amide compounds have good inhibition effects on Xanthomonas oryzae pv.Oryza (Xoo), Xanthomonas oryzae pv.Oryzcola (Xoc) and Xanthomonas axonophora pv.Citri (Xac) in agricultural diseases and insect pests, and can be used for preparing the anti-plant bacterium agent.

Synthesis and Antibacterial Evaluation of N-phenylacetamide Derivatives Containing 4-Arylthiazole Moieties

A series of new N-phenylacetamide derivatives containing 4-arylthiazole moieties was designed and synthesized by introducing the thiazole moiety into the amide scaffold. The structures of the target compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. Their in vitro antibacterial activities were evaluated against three kinds of bacteria-Xanthomonas oryzae pv. Oryzae (Xoo), Xanthomonas axonopodis pv. Citri (Xac) and X.oryzae pv. oryzicola (Xoc)-showing promising results. The minimum 50% effective concentration (EC50) value of N-(4-((4-(4-fluoro-phenyl)thiazol-2-yl)amino)phenyl)acetamide (A1) is 156.7 μM, which is superior to bismerthiazol (230.5 μM) and thiodiazole copper (545.2 μM). A scanning electron microscopy (SEM) investigation has confirmed that compound A1 could cause cell membrane rupture of Xoo. In addition, the nematicidal activity of the compounds against Meloidogyne incognita (M. incognita) was also tested, and compound A23 displayed excellent nematicidal activity, with mortality of 100% and 53.2% at 500 μg/mL and 100 μg/mL after 24 h of treatment, respectively. The preliminary structure-activity relationship (SAR) studies of these compounds are also briefly described. These results demonstrated that phenylacetamide derivatives may be considered as potential leads in the design of antibacterial agents.

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against: Klebsiella pneumoniae

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). Some of the synthesized compounds exhibited synergistic activity. When 4 μg ml-1 compound B1 was combined with PB, it showed potent antibacterial activity, achieving 64-fold reduction of the MIC of PB. Furthermore, compound B1 showed prominent synergistic efficacy in both concentration gradient and time-kill curves in vitro. In addition, B1 combined with PB also exhibited synergistic and partial synergistic effect against E. coli (ATCC25922 and its clinical isolates), Acinetobacter baumannii (ATCC19606 and its clinical isolates), and Pseudomonas aeruginosa (Pae-1399).

Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)

Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 0.39μM) of FMDV 3D polymerase and compound 24a (EC50=13.09 μM) showed more potent antiviral activity than ribavirin (EC50=1367 μM) and T1105 (EC50=347 μM) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain.