1614-92-2

Basic information

• Product Name: 1-(1-CYCLOPENTENYL)PIPERIDINE
• Synonyms: N-(CYCLOPENTEN-1-YL)PIPERIDINE;1-(1-CYCLOPENTENYL)PIPERIDINE;1-CYCLOPENT-1-ENYL-PIPERIDINE;1-(CYCLOPENTEN-1-YL)PIPERIDINE;1-(1-Cyclopenten-1-yl)piperidine;1-Piperidino-1-cyclopentene;1-Piperidinocyclopentene;1-(Piperidine-1-yl)cyclopentene
• CAS NO: 1614-92-2
• Molecular Formula: C₁₀H₁₇N
• Molecular Weight: 151.25
• Mol File: 1614-92-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 241.9 °C at 760 mmHg
• Flash Point: 91.4 °C
• Appearance: Gray-white power
• Density: 1 g/cm³
• Vapor Pressure: 0.0349mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 1-(1-CYCLOPENTENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-CYCLOPENTENYL)PIPERIDINE(1614-92-2)
• EPA Substance Registry System: 1-(1-CYCLOPENTENYL)PIPERIDINE(1614-92-2)

Safety Data

• Hazardous Substances Data: 1614-92-2(Hazardous Substances Data)

Usage

General Description

1-(1-cyclopentenyl)piperidine is an organic compound consisting of a piperidine ring with a cyclopentenyl group attached to one of its nitrogen atoms. It is a heterocyclic compound that is used in the synthesis of pharmaceuticals and other organic compounds. The cyclopentenyl group adds additional structural diversity and reactivity to the piperidine ring, making it a valuable building block for drug discovery and development. This chemical is also a potent inhibitor of acyl-coenzyme A: cholesterol acyltransferase, an enzyme involved in cholesterol metabolism. Additionally, 1-(1-cyclopentenyl)piperidine has been studied for its potential biological activity and therapeutic applications.

InChI:InChI=1/C10H17N/c1-4-8-11(9-5-1)10-6-2-3-7-10/h6H,1-5,7-9H2

Upstream product

• 110-89-4 piperidine 
• 120-92-3 cyclopentanone 
• 142-29-0 cyclopentene 

Downstream Products

• 4594-77-8 2-oxocyclopentanepropiononitrile 
• 58712-11-1 methyl 3-(2-oxo-cyclopentyl)propanoate 
• 98147-16-1 3-(4-chloro-phenyl)-6a-piperidin-1-yl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole 
• 39076-64-7 2-phenyl-4a-piperidin-1-yl-5,6,7,7a-tetrahydro-4aH-cyclopenta[e][1,3]oxazin-4-one 
• 39076-67-0 N-Benzoyl-2-oxocyclopentan-1-carbonsaeureamid 
• 1624-26-6 2,3-dihydro-1H-cyclopenta[b]naphthalene 
• 5661-06-3 2,3-dihydro-1H-cyclopenta[b]quinoline 
• 83465-97-8 (4R,4aS,7aS)-3-Methyl-4-phenyl-7a-piperidin-1-yl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,2]oxazine 2-oxide 
• 73765-59-0 3-Phenyl-3,5,6,7-tetrahydrocyclopenta1,2,3-triazolo<4,5-b>pyridine 
• 13225-63-3 2,3-Dihydro-4-phenyl-1H-benzindene 
• 53263-53-9 2-phenylamino-2-cyclopenten-1-one 
• 147723-54-4 2-(4'-Morpholino-thiocarbonylthio)cyclopentanon 
• 112423-31-1 9,10-Dihydro-7-phenylcyclopentachinolizin-6(8H)-on 
• 125986-49-4 N-tert-Butyl-N'-(4-nitro-phenyl)-3-(2-oxo-cyclopentyl)-propionamidine 

Relevant articles and documents

An enamine/HB(C6F5)2 adduct as a dormant state in frustrated lewis pair chemistry

The enamine piperidinocyclopentene reacts with HB(C6F 5)2 by formation of the C-Lewis base/B-Lewis acid adduct 10. It shows a zwitterionic iminium ion/hydridoborate structure. However, this adduct formation is apparently reversible and may generate the "invisible" frustrated Lewis pair 11 as a reactive intermediate by hydroboration of the enamine C=C bond in an equilibrium situation at room temperature. Consequently, the FLP 11 was trapped by typical FLP reactions, namely by the reaction with dihydrogen to give the ammonium/hydridoborate 12, the acetylene deprotonation products 13 and 14, and simple borane adducts with pyridine (15) and with an isonitrile (17). The products 10 and 12-15 and the isonitrile adduct 17 were characterized by X-ray diffraction. A DFT study determined the thermodynamic features of the 10 a? 11 equilibrium and of a previously discussed reference system (18 a? 19) derived by reacting piperidinocyclohexene with HB(C6F5)2.

Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones

Based on the Tf2O-mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis.

Synthesis, structure and thermal decomposition of cycloalkanone enamine peroxides

Reactions of cycloalkanone enamines with H2O2 gave bis(1-morpholinocyclopent-1-yl)- and bis(1-morpholinocyclohex-1-yl)-peroxides, which were studied by NMR spectroscopy and X-ray diffraction. Thermolysis of bis(1-morpholinocyclohex-1-yl)-peroxide in n-hexane resulted in two major products, viz., cyclohexanone and morpholine.