1614228-74-8

Basic information

• Product Name: (R)-ethyl-3-(2-(4-(tert-butoxy)-3,4-dioxo-1-phenylbutan-2-yl)hydrazinyl)-1H-pyrrole-2-carboxylate
• Synonyms: (R)-ethyl-3-(2-(4-(tert-butoxy)-3,4-dioxo-1-phenylbutan-2-yl)hydrazinyl)-1H-pyrrole-2-carboxylate
• CAS NO: 1614228-74-8
• Molecular Weight: 401.462
• Mol File: 1614228-74-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-ethyl-3-(2-(4-(tert-butoxy)-3,4-dioxo-1-phenylbutan-2-yl)hydrazinyl)-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl-3-(2-(4-(tert-butoxy)-3,4-dioxo-1-phenylbutan-2-yl)hydrazinyl)-1H-pyrrole-2-carboxylate(1614228-74-8)
• EPA Substance Registry System: (R)-ethyl-3-(2-(4-(tert-butoxy)-3,4-dioxo-1-phenylbutan-2-yl)hydrazinyl)-1H-pyrrole-2-carboxylate(1614228-74-8)

Safety Data

• Hazardous Substances Data: 1614228-74-8(Hazardous Substances Data)

Upstream product

• 18942-49-9 Boc-D-Phe-OH 
• 252932-48-2 3-amino-2-ethoxycarbonylpyrrole 
• 1021175-71-2 diethyl 2-(2-cyanovinylamino)malonate 

Relevant articles and documents

Synthesis and reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione. Access to new pyrrolo[3,2-e][1,4]diazepine-2,5-diones

A convenient synthesis of pyrrolo[3,2-d][1,3]oxazine-2,4-dione 4 is described and its reactivity towards various nucleophiles studied. The regioselective ring opening of anhydride 4 or its N-alkylated analog 25 in the presence of alanine or proline afforded, respectively, imidazolidinedione 22 and N-protected pyrrolo[3,2-e][1,4]diazepines 30 and 31 in a one-pot process. In a last part of this study, an alternative route to produce a library of eight non protected pyrrolo[3,2-e][1,4]diazepine-2,5-diones 35a-h is described to overcome the limited reactivity of anhydride 4.