1614248-13-3Relevant academic research and scientific papers
Enantioselective Pd-catalyzed allylation of acyclic α-fluorinated ketones
Wang, Wengui,Shen, Haiming,Wan, Xiao-Long,Chen, Qing-Yun,Guo, Yong
, p. 6347 - 6353 (2014)
Significant synthetic challenges remain for the asymmetric synthesis of tertiary α-fluoro ketones, which are potentially useful molecules for the development of drugs, agrochemicals, and functional materials. Herein, we describe the development of a method for the catalytic enantioselective synthesis of tertiary α-fluoro ketones via the Tsuji-Trost reaction of racemic acyclic α-fluorinated ketones. Enantioenriched acyclic α-cabonyl tertiary fluorides can be produced with the aid of a palladium/phosphinooxazoline catalyst.
