161431-57-8 Usage
General Description
The chemical 8-(trifluoromethyl)quinolin-5-amine, also known as TFAQA, is a derivative of quinoline with a trifluoromethyl group attached to the eighth position and an amine group attached to the fifth position. 8-(trifluoromethyl)quinolin-5-amine is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, particularly in the development of new drugs. The trifluoromethyl group enhances the lipophilicity and metabolic stability of the molecule, making it a valuable component in drug design. Additionally, the amine group provides the potential for further functionalization, allowing for the creation of diverse chemical structures with potential therapeutic properties. Overall, TFAQA is an important chemical in drug discovery and development due to its versatile and valuable properties.
Check Digit Verification of cas no
The CAS Registry Mumber 161431-57-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,4,3 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 161431-57:
(8*1)+(7*6)+(6*1)+(5*4)+(4*3)+(3*1)+(2*5)+(1*7)=108
108 % 10 = 8
So 161431-57-8 is a valid CAS Registry Number.
161431-57-8Relevant articles and documents
Experimental and Computational Studies of Trifluoromethylation of Aromatic Amines by the System Trifluoroiodomethane-Zinc-Sulfur Dioxide
Strekowski, Lucjan,Hojjat, Maryam,Petterson, Steven E.,Kiselyov, Alexander S.
, p. 1413 - 1416 (2007/10/02)
Several trifluoromethyl-substituted aromatic and heteroaromatic amines have been obtained by the reactions of the corresponding amines with the title reagent system.Computational results provide rationalization for the observed regioselectivities and support a mechanism in which the electrophilic trifluoromethyl radicals interact with the aromatic ring at the sites with the greatest electron density of the HOMO orbitals, and then the resultant adducts are oxidized to cations.The products obtained are potential building blocks for a number of heterocyclic systems.
