161446-90-8

Basic information

• Product Name: 3-CHLORO-4-FLUOROBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 0222;3-chloro-4-fluorobenzylalcohol97%;(3-CHLORO-4-FLUORO-PHENYL)-METHANOL;3-CHLORO-4-FLUOROBENZYL ALCOHOL;3-Chloro-4-fluorobenzyl alcohol 97%;3-Chloro-4-fluorobenzylaalcohol;3-Chloro-4-fluorobenzenemethanol;(3-Chloro-4-fluorophenyl)
• CAS NO: 161446-90-8
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.57
• EINECS: -0
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Fluorine series
• Mol File: 161446-90-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 243℃
• Flash Point: 100℃
• Appearance: /
• Density: 1.344
• Vapor Pressure: 0.0183mmHg at 25°C
• Refractive Index: 1.5355
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13?+-.0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-CHLORO-4-FLUOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-FLUOROBENZYL ALCOHOL(161446-90-8)
• EPA Substance Registry System: 3-CHLORO-4-FLUOROBENZYL ALCOHOL(161446-90-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 161446-90-8(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

Uses

3-Chloro-4-fluorobenzyl alcohol is used as a pharmaceutical intermediate.

InChI:InChI=1/C7H6ClFO/c8-6-3-5(4-10)1-2-7(6)9/h1-3,10H,4H2

Upstream product

• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 
• 403-16-7 3-chloro-4-fluorobenzoic acid 

Downstream Products

• 192702-01-5 3-chloro-4-fluorobenzyl bromide 
• 1055393-17-3 C₁₉H₁₈Cl₂FN₃O₃ 
• 888073-57-2 (1S,2R,3R,5R,6S)-2-Azido-3-(3-chloro-4-fluoro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester 
• 820260-57-9 (1S,2R,3R,5R,6S)-2-Amino-3-(3-chloro-4-fluoro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester 
• 1620217-65-3 4-benzyl-2-chloro-1-fluorobenzene 
• 1440519-55-0 N-[2-(3-chloro-4-fluoro-phenyl)-ethyl]-2,2,2-trifluoro-acetamide 
• 244194-67-0 2-(3-chloro-4-fluoro-phenyl)-ethylamine 
• 658-98-0 2-(3-chloro-4-fluorophenyl)acetonitrile 

Relevant articles and documents

Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives

A series of pyrazoline derivatives and corresponding chalcone intermediates with substituents same as combretastatin-A4(CA-4) conjugated with triazole nucleus has been synthesized and evaluated for their anticancer potential. Sulphorhodamine B(SRB) assay indicated compound 12c to be the most active compound from the series with GI50 value of 6.7 μm against the human liver carcinoma cell line HepG2. Interestingly, the intermediate 11c exhibited more promising cytotoxicity demonstrating GI50 value of 1.3 μm against the prostate cancer cell line DU145. Compounds 11c and 12c caused accumulation of cells in G2/M phase and inhibited tubulin polymerization. Furthermore, these compounds reduce the mitochondrial membrane potential and activate caspases 3 and 9, thereby indicating their ability to trigger apoptosis.

Anti-tubercular agents. Part 8: Synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles

A series of 5-nitrofuran-triazole conjugates were synthesized and evaluated for their antimicrobial activity against both Gram-positive and Gram-negative bacterial strains. All the compounds exhibited promising inhibition towards Gram-positive pathogenic strains, while mild inhibitory effects were observed towards Gram-negative bacterial strains. Some of the compounds 8a, 8b, 8e, 8f, 8h are most active among the series exhibiting MIC value of 1.17 μg/ml against different bacterial strains. The bactericidal activity is found to be in accordance with the bacterial growth inhibition data. Compound 8e was found to be equipotent to the standard drug Ciprofloxacin displaying MBC value of 1.17 μg/ml against the bacterial strain Bacillus subtilis. The compounds have also demonstrated promising antibacterial activity against the resistant strain MRSA and were found to be effective inhibitors of biofilm formation. The compound 8b exhibited excellent anti-biofilm activity with IC50 value as low as 0.8 μg/ml. These conjugates were also screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Compound 8e showed promising antitubercular activity with MIC value of 0.25 μg/ml. Most of these compounds are less toxic to normal mammalian cells than the widely used antibacterial drug Ciprofloxacin.

Indole derivatives and their use as MCP-1 antagonist

A compound of formula (1) wherein R1 is hydrogen, halo or methoxy, R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or —CONHSO2R4where R4is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is —CH2— or —SO2—; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed. These compounds and compositions are useful in the treatment of disease mediated by monocyte chemoattractant protein-1 or RANTES (Regulated Upon Activation, Normal T-cell Expressed and Secreted), such as inflammatory disease.