161448-78-8

Basic information

• Product Name: 2-NAPHTHYLMETHANESULFONYL CHLORIDE
• Synonyms: 2-NAPHTHYLMETHANESULFONYL CHLORIDE;NAPHTHALEN-2-YLMETHANESULFONYL CHLORIDE
• CAS NO: 161448-78-8
• Molecular Formula: C₁₁H₉ClO₂S
• Molecular Weight: 240.71
• Mol File: 161448-78-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 395.5±21.0 °C(Predicted)
• Appearance: /
• Density: 1.397±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-NAPHTHYLMETHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NAPHTHYLMETHANESULFONYL CHLORIDE(161448-78-8)
• EPA Substance Registry System: 2-NAPHTHYLMETHANESULFONYL CHLORIDE(161448-78-8)

Safety Data

• Hazardous Substances Data: 161448-78-8(Hazardous Substances Data)

Upstream product

• 91-57-6 2-Methylnaphthalene 
• 2506-41-4 1-chloromethylnaphthalene 
• 939-26-4 2-bromomethylnaphthyl bromide 

Downstream Products

• 348081-06-1 (R)-(naphthalen-2-ylmethanesulfonylamino)-2-phenyl-acetic acid 
• 348081-08-3 (R)-2-(napthalen-2-ylmethanesulfonylamino)-4-phenylbutyric acid 
• 683813-02-7 methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(2-{[(2-naphthylmethyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoate 

Relevant articles and documents

Synthesis of novel dihydronaphthothiazine S,S-dioxides by intramolecular sulfonylamidomethylation of 2-naphthylmethanesulfonamides using Amberlyst XN-1010

We describe herein an efficient synthetic method for novel dihydronaphthothiazines S,S-dioxides by aromatic intramolecular sulfonylamidomethylation of 2-naphthylmethanesulfonamides with s-trioxane using Amberlyst XN-1010 as acid heterogeneous catalyst. Cyclization of the formed sulfonyliminium ion occurred with high regioselectivity and in excellent yields.

Designing anti-inflammatory drugs from parasitic worms: A synthetic small molecule analogue of the acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis

In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We have approached this matter in a novel manner by synthesizing a library of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflammatory Acanthocheilonema viteae product, ES-62, which as an immunogenic protein is unsuitable for use as a drug. Following preliminary in vitro screening for inhibitory effects on relevant macrophage cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testing in an in vivo model of inflammation, collagen-induced arthritis (CIA). Testing revealed that 11a was as effective as ES-62 in protecting DBA/1 mice from developing CIA and mirrored its mechanism of action in downregulating the TLR/IL-1R transducer, MyD88. 11a is thus a novel prototype for anti-inflammatory drug development.

Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.