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161459-96-7

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161459-96-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 161459-96-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,4,5 and 9 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 161459-96:
(8*1)+(7*6)+(6*1)+(5*4)+(4*5)+(3*9)+(2*9)+(1*6)=147
147 % 10 = 7
So 161459-96-7 is a valid CAS Registry Number.

161459-96-7Downstream Products

161459-96-7Relevant articles and documents

A novel class of inhibitors for human steroid 5α-reductase: Synthesis and biological evaluation of indole derivatives. II

Igarashi, Susumu,Inami, Hiroshi,Hara, Hiromu,Fujii, Masahiro,Koutoku, Hiroshi,Oritani, Hiroyuki,Mase, Toshiyasu

, p. 382 - 388 (2007/10/03)

In a search for novel nonsteroidal inhibitors of human prostatic 5α- reductase, we found a new series of indole derivatives that showed potent inhibitory activities for the human enzyme. Among them, 4-[(1-benzyl-1- Hindol-5-yl)oxy]-3-chlorobenzoic acid (2d, YM-32906) showed more potent inhibitory activity than finasteride with an IC50 value of 0.44 nM. 3- Chloro-4-{[1-(4-phenoxybenzyl)-1H-indol-5-yl]oxy}benzoic acid (2m) showed inhibitory activities for both human and rat prostatic 5α-reductase with IC50 values of 2.1 and 73 nM, respectively. The synthesis and structure- activity relationships of these indole derivatives are presented.

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