161466-19-9

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 24393-59-7 (E)-ethyl 3-(2-nitrophenyl)acrylate 
• 3770-50-1 2-carbethoxyindole 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1215215-46-5 ethyl 2-hydroxy-1-(4-methoxybenzyl)-3-oxo-1,2-dihydro-3H-indol-2-carboxylate 
• 1360148-56-6 [1-(4-methoxy-benzyl)-1H-indol-2-yl]-methanol 
• 1360148-41-9 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-hex-5-en-1-ol 
• 1360148-43-1 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-but-3-en-1-ol 
• 1360148-44-2 acetic acid 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-hex-5-enyl ester 
• 1360148-46-4 acetic acid 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-but-3-enyl ester 
• 1360148-48-6 acetic acid 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-oxopentyl ester 
• 1360148-50-0 acetic acid 5-hydroxy-1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-hexyl ester 
• 1360148-38-4 acetic acid 1-[1-(4-methoxy-benzyl)-1H-indol-2-yl]-5-oxo-hexyl ester 
• 411229-93-1 Ethyl 3-[(4-methoxyphenyl)methyl]indole-2-carboxylate 
• 3770-50-1 2-carbethoxyindole 

Relevant academic research and scientific papers

Synthetic approaches to natural antioxidant benzastatin E, F and G analogues

For synthesis of benzastatin E, F and G analogues, the indole-2- carbaldehydes with or without substituents at C-5 position were prepared as key intermediates. Several synthetic attempts to achieve benzastatin E-G analogues were suggested using the indole-2-carbaldehyde intermediates.

Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction

A novel preparative method for 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones through the oxidation of 2-arylindoles followed by a Mannich-type reaction with carbon nucleophiles is described.

Synthetic studies on indoles and related compounds. XXVI. The debenzylation of protected indole nitrogen with aluminum chloride. (2)

A new debenzylation method using aluminum chloride in benzene or anisole, which had been developed by us for N-benzyl-2-acyl- and -2-ethoxycarbonylindoles, was applied to benzyl derivatives of other types of indoles and related compounds. Among them, N-benzyl derivatives of fully aromatized indoles, carbazoles and β-carbolines, and some benzamides were debenzylated successfully, whereas those of oxindoles and heterocyclic amides were not. As to the effect of a p-substituent on the benzyl group, it was found that an electron-donating substituent accelerates deprotection, whereas an electron-attracting substituent delays or prevents deprotection.