161491-32-3

Basic information

• Product Name: 1-(2,2-diphenylacetyl)-4-Piperidinone
• Synonyms: 1-(2,2-diphenylacetyl)-4-Piperidinone
• CAS NO: 161491-32-3
• Molecular Weight: 0
• Mol File: 161491-32-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2,2-diphenylacetyl)-4-Piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-diphenylacetyl)-4-Piperidinone(161491-32-3)
• EPA Substance Registry System: 1-(2,2-diphenylacetyl)-4-Piperidinone(161491-32-3)

Safety Data

• Hazardous Substances Data: 161491-32-3(Hazardous Substances Data)

Usage

General Description

1-(2,2-diphenylacetyl)-4-Piperidinone, also known as Dibenzoylmethane, is a chemical compound that belongs to the class of aromatic ketones. It is commonly used as a UV filter in sunscreen products due to its ability to absorb a wide range of ultraviolet radiation. 1-(2,2-diphenylacetyl)-4-Piperidinone is also known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products. Additionally, 1-(2,2-diphenylacetyl)-4-Piperidinone has been studied for its potential therapeutic effects, including its ability to inhibit the growth of certain cancer cell lines and its potential use in the treatment of neurodegenerative diseases. Overall, this chemical compound has a wide range of applications and continues to be the subject of ongoing research for its various potential benefits.

Upstream product

• 1871-76-7 diphenylacetic acid chloride 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 40064-34-4 piperidine-4,4-diol hydrochloride 

Downstream Products

• 292059-40-6 N-(diphenyl)acetyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 455323-44-1 N-(diphenyl)acetyl-4-[3-(methoxycarbonyl)benzylidene]piperidine 
• 455323-48-5 N-(diphenyl)acetyl-4-[(2-methoxy-4-methoxycarbonyl)benzylidene]piperidine 
• 161491-33-4 N-Diphenylacetyl-4-piperidone-3-carboxaldehyde 

Relevant articles and documents

Synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors of steroid-5α-reductase type 1 and 2

The synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) is described [benzoyl (1Scheme 2Synthetic strategy.), benzyl (2), adamantanoyl (3), cyclohexanoyl (4), cyclohexylacetyl (5), diphenylacetyl (6), dicyclohexylacetyl (7), 2-propylpentanoyl (8), diphenylcarbamoyl (9), trimethylacetyl (10), 3,3-dimethylacryloyl (11), dicyclohexylacetyl derivative of the benzyl compound (12)]. Compounds were tested for inhibitory activity toward 5α-reductase isozymes 1 and 2 in human and rat. The test compounds inhibited 5α-reductase, showing a broad range of inhibitory potencies. In rat, compounds 6 (IC50=3.44 and 0.37 μM for type 1 and 2, respectively) and 9 (IC50=0.54 and 0.69 μM for type 1 and 2, respectively) displayed the best inhibition toward both isozymes. Compound 7 showed a strong inhibition toward type 2 human and rat enzyme (IC50=60 and 80 nM) but only a moderate activity versus type 1 enzyme (IC50 approximately 10 μM for rat and human enzyme). In vivo, selected compounds reduced prostate weights in castrated testosterone treated rats. Copyright (C) 2000 Elsevier Science Ltd.