161523-78-0Relevant articles and documents
Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors - Reducing the lipophilicity of the arachidonyl chain isostere
Walters, Iain,Bennion, Colin,Connolly, Stephen,Croshaw, Pamela J.,Hardy, Kim,Hartopp, Paul,Jackson, Clive G.,King, Sarah J.,Lawrence, Louise,Mete, Antonio,Murray, David,Robinson, David H.,Stein, Linda,Wells, Edward,Withnall, W. John
, p. 3645 - 3649 (2007/10/03)
The high lipophilicity of a series of cytosolic phospholipase A2 inhibitors has been reduced by the modification of a decyloxyphenyl chain designed to mimic the arachidonyl group of the natural substrate. These changes have resulted in an improvement in the whole cell potency of the inhibitors.
