1615239-33-2Relevant academic research and scientific papers
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: Design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase
Peduto, Antonella,Bruno, Ferdinando,Dehm, Friedrike,Krauth, Verena,De Caprariis, Paolo,Weinigel, Christina,Barz, Dagmar,Massa, Antonio,De Rosa, Mario,Werz, Oliver,Filosa, Rosanna
, p. 492 - 498 (2014/06/10)
5-Lipoxygenase (5-LO), an enzyme that catalyzes the initial steps in the biosynthesis of pro-inflammatory leukotrienes, is an attractive drug target for the pharmacotherapy of inflammatory and allergic diseases. Here, we present the design, synthesis and
