161529-22-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 84890-97-1 (S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 79069-16-2 benzyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate 

Downstream Products

• 1403953-50-3 (3S)-benzyl 3-amino-4-iodobutanoate hydrochloride 
• 1403953-51-4 (3S)-benzyl 3-(diphenylmethylideneamino)-4-iodobutanoate 
• 1403953-53-6 (1R,2R)-benzyl 2-(diphenylmethylideneamino)cyclopropanecarboxylate 
• 142895-04-3 Boc-β³-Cys(Ac)-OBn 
• 1429399-44-9 benzyl (3S)-4-{[(2R)-2-amino-3-ethoxy-3-oxopropyl]thio}-3-[(tert-butoxycarbonyl)amino]butanoate 
• 167216-17-3 (-)-tert-butyl [(R)-3-hydroxy-1-methylpropyl]carbamate 

Relevant academic research and scientific papers

Novel thiol- and thioether-containing amino acids: Cystathionine and homocysteine families

Natural l-homocysteine and l,l-cystathionine, along with a series of unnatural analogues, have been prepared from l-aspartic and l-glutamic acid. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation react

Stereoselective synthesis of both enantiomers of trans-2- (diphenylmethylideneamino)cyclopropanecarboxylic acid using a chiral pool approach and their incorporation in dipeptides

The stereoselective synthesis of (1R,2R)- and (1S,2S)-trans-2- (diphenylmethylideneamino)cyclopropanecarboxylic acid has been accomplished in six steps starting from (2S)- and (2R)-β-benzyl N-(tert-butoxycarbonyl) aspartate, respectively. The key-step in

1,3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES

Compounds of formula Ia or Ib in free or salt form, wherein Ar, X1, X2, m, R1, Q, Y, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic cond

Chiral N-Protected β-Iodoamines from α-Aminoacids: a General Synthesis

N-Protected D- or L-β-iodoamines (as 2), which are useful intermediates for the preparation of chiral β-aminoacids, are obtained smoothly from β-aminols (as 1) in two steps and high yields.

Synthesis of enantiopure N-and C-protected homo-β-amino acids by direct homologation of α-amino acids

Enantiopure N-and/or C-protected homo-β-amino acids are prepared readily and in good yields from N-protected α-amino acids with the same side chain, via reduction of the carboxyl function and conversion of the resulting N-protected β-amino alcohol into the corresponding β-amino iodide and then β-amino cyanide. The key step of this strategy is represented by the synthesis of the enantiopure N-protected β-amino iodides 2 and 3 that are smoothly obtained from the parent amino alcohols 1 by polymer bound triarylphosphine-I2 complex in anhydrous dichloromethane.