16154-78-2

Usage

Uses

Due to the limited information available about 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole monohydrochloride, its exact applications are not well-defined. However, given its complex structure and classification as a heterocyclic compound, it is likely used in specialized research or industrial applications. The potential uses could include:
Used in Research Applications:
2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole monohydrochloride is used as a research compound for studying its chemical properties and potential interactions with other molecules.
Used in Pharmaceutical Industry:
Although not explicitly mentioned, compounds with similar structures are often explored for their potential pharmaceutical applications. 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole monohydrochloride could be used as a starting material or intermediate in the synthesis of pharmaceutical compounds.
Used in Chemical Synthesis:
2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole monohydrochloride may also be utilized in the synthesis of other complex organic molecules, where its unique structure could provide specific reactivity or properties that are desirable in the final product.

InChI:InChI=1/C15H18N2.ClH/c1-10-5-6-14-12(9-10)11-3-2-4-13-15(11)17(14)8-7-16-13;/h5-6,9,13,16H,2-4,7-8H2,1H3;1H

Upstream product

• 15932-34-0 5,6-dihydro-8-methyl-4H-pyrazino<3,2,1-j,k>carbazole hydrochloride 
• 110951-52-5 (2-Chloro-ethyl)-(6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-amine 
• 110951-48-9 6-Methyl-1-(2-hydroxyethylimino)-1,2,3,4-tetrahydrocarbazole 
• 110951-51-4 6-Methyl-1-(2-chloroethylimino)-1,2,3,4-tetrahydrocarbazole hydrochloride 
• 3449-48-7 6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 73166-21-9 8-Methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole; hydrochloride 
• 145100-72-7 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole 

Downstream Products

• 73166-21-9 8-Methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole; hydrochloride 

Relevant academic research and scientific papers

Process for the preparation of pirlindole hydrochloride

Process for the synthesis of pirlindole hydrochloride of formula (I) characterized in that the 6-methyl-1-(2-chloroethyl-imino)-1,2,3,4-tetrahydrocarbazol hydrochloride cyclizes to yield 1,2,5,6-tetrahydro-8-methyl-pyrazine[3,2,1-j,k]-4H-carbazol of formula (VI) which is subjected to reduction.

First Preparative Enantiomer Resolution of Pirlindole, a Potent Antidepressant Drug

Pirlindole is an antidepressant drug. It acts principally as reversible inhibitor of monoamine oxidase-A (RIMA) and appears relatively potent in comparison with reference drugs. Pirlindole possesses stereogenic center but is generally used as racemate. In this work, the first preparative resolution of its enantiomeric couple is described. Whereas selective crystallization of salts of chiral acid failed, two asymmetric synthetic pathways were also examined; however, without success. Finally separation and isolation of enantiomers of pirlindole was completed by using the derivatization method coupled with preparative HPLC. Optical purity of each isomer was determined by chiral HPLC. The specific rotation of each antipode was also determined.

New Simple Laboratory Method for the Synthesis of Pirazidol

5,6-Dihydro-8-methyl-4H-pyrazinocarbazole was obtained by the reaction of α-bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid.The reduction of 5,6-dihydro-8-methyl-4H-pyrazinocarbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazinocarbazole hydrochloride - the medicinal preparation pirazidol.