16155-51-4Relevant articles and documents
Synthesis and pharmacological evaluation of 2,3-dialkylindoles, 'in vitro' inhibitors of thrombin-induced platelet aggregation
Arcari,Aveta,Brandt,Cecchetelli,Corsi,Solinas
, p. 405 - 425 (2007/10/02)
A series of 2,3-dialkylindoles (1-5) have been prepared and tested as antithrombotic agents. The whole class showed in vitro interesting activity in the inhibition of thrombin-induced aggregation. Among these compounds some ones showed activity comparable to standards also in the inhibition of collagen-induced aggregation. Owing to a very fast metabolic degradation through a beta-oxidative mechanism, a drastic decrease of activity in several tests ex vivo or in vivo was observed.
