161557-60-4Relevant articles and documents
Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for β-amyloid plaques
Swahn, Britt-Marie,Wensbo, David,Sandell, Johan,Sohn, Daniel,Slivo, Can,Pyring, David,Malmstr?m, Jonas,Arzel, Erwan,Vallin, Michaela,Bergh, Margareta,Jeppsson, Fredrik,Johnson, Allan E.,Juréus, Anders,Neelissen, Jan,Svensson, Samuel
, p. 1976 - 1980 (2010)
The syntheses and SAR of new series of β-amyloid binding agents are reported. The effort to optimize signal-to-background ratios for these ligands are described. Compounds 8, 21 and 30 displayed desirable lipophilicity and pharmacokinetic properties. Compounds 8 and 21 were evaluated with in vitro autoradiographic studies and in vivo in APP/PS1 transgenic mice. It is shown that it was possible to increase the signal-to-background ratios compared to PIB 1, as demonstrated by compounds 8 and 21.
2-Hydroxy-4,6-diamino-[1,3,5]triazines: A novel class of VEGF-R2 (KDR) tyrosine kinase inhibitors
Baindur, Nand,Chadha, Naresh,Brandt, Benjamin M.,Asgari, Davoud,Patch, Raymond J.,Schalk-HiHi, Celine,Carver, Theodore E.,Petrounia, Ioanna P.,Baumann, Christian A.,Ott, Heidi,Manthey, Carl,Springer, Barry A.,Player, Mark R.
, p. 1717 - 1720 (2007/10/03)
2-Hydroxy-4,6-diamino-[1,3,5]triazines are described which are a novel class of potent inhibitors of the VEGF-R2 (flk-1/KDR) tyrosine kinase. 4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-ol (14d) exhibited low nanomolar potency i