1615654-85-7Relevant academic research and scientific papers
Copper-catalyzed enantioselective hetero-diels-alder reaction of Danishefsky's diene with β,γ-unsaturated α-ketoesters
Hu, Yanbin,Xu, Kun,Zhang, Sheng,Guo, Fengfeng,Zha, Zhenggen,Wang, Zhiyong
, p. 3564 - 3567 (2014)
A highly enantioselective hetero-Diels-Alder reaction of Danishefskys diene with β,γ-unsaturated α-ketoesters was developed for the first time by virtue of chiral copper complexes. This protocol provided a facile access to optically active dihydropyranones bearing a quaternary center with high enantioselectivities and good yields. Furthermore, on the basis of the isolated intermediate analysis, the reaction pathway was substrate-dependent.
