1615684-96-2

Upstream product

• 1615684-93-9 1,3-dihydro-6-(2-formylpyrrol-1-yl)-1-hydroxy-2,1-benzoxaborole 
• 1344109-52-9 6-(pyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 1344109-47-2 2-bromo-4-(pyrrol-1-yl)benzyl alcohol 
• 1344109-43-8 2-bromo-4-(pyrrol-1-yl)benzoic acid methyl ester 
• 98545-64-3 methyl-2-bromo-4-aminobenzoate 
• 100959-22-6 methyl 2-bromo-4-nitrobenzoate 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 856794-72-4 2-bromo-4-nitrobenzoyl chloride 
• 1615684-94-0 1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-1H-pyrrole-2-carboxylic acid 
• 108-91-8 cyclohexylamine 

Relevant academic research and scientific papers

Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 μg/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure-activity relationship of the pyrrolobenzoxaboroles are also discussed.