1615687-82-5

Basic information

• Product Name: (1R,4R)-1-((R)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
• Synonyms: (1R,4R)-1-((R)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
• CAS NO: 1615687-82-5
• Molecular Weight: 360.472
• Mol File: 1615687-82-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,4R)-1-((R)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4R)-1-((R)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one(1615687-82-5)
• EPA Substance Registry System: (1R,4R)-1-((R)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one(1615687-82-5)

Safety Data

• Hazardous Substances Data: 1615687-82-5(Hazardous Substances Data)

Upstream product

• 53585-70-9 (+)-7,7-dimethyl-1-vinyl-2-norbornanone 
• 21286-54-4 Camphorsulfonyl chloride 
• 2252-63-3 1-(4-Fluorophenyl)piperazine 

Relevant articles and documents

Antimycobacterial activity of chiral aminoalcohols with camphane scaffold

A series of aminoalcohols were synthesized by reaction of aminolysis of camphor derived oxiranes with chosen amines. The compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv. Ten of the new structures show much higher activity than the classical anti-TB drug ethambutol. Some of the most active compounds were tested against MDR strain 43, and four of them demonstrated excellent activities with MICs 0.27-0.72 μM. The cytotoxicity of representative exerting antimycobacterial activity compounds was assessed. Quantitative structure-activity relationship (QSAR) model is derived to estimate the contribution of each structural fragment to the activity. The camphane-based aminoalcohols are promising lead compounds for further development of novel antimycobacterial agents.