161574-32-9

Upstream product

• 1199-01-5 2-phenylazlactone 
• 1663-39-4 tert-Butyl acrylate 
• 495-69-2 Hippuric Acid 

Downstream Products

• 172095-27-1 (rac)-3-(4-methyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-propionic acid tert.-butyl ester 
• 182176-37-0 rac-(tert-butyl) 4-<(benzyloxycarbonyl)methyl>-4,5-dihydro-5-oxo-2-phenyloxazole-4-propanoate 

Relevant academic research and scientific papers

PROCESSES FOR PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE

Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

A reinvestigation of the α-alkylation of 4-monosubstituted 2-phenyloxazol-5(4H)-ones ('azlactones'): A general entry into highly functionalized α,α-disubstituted α-amino acids

Novel, more reliable and general reaction conditions for the α-alkylation of 4-monosubstituted 2-phenyloxazol-5(4H)-ones (= 4-monosubstituted 2-phenyl-azlactones) rac-2 to 4,4-disubstituted 2-phenyloxazol-5(4H)-ones rac-1 were found. Thus, a whole range of highly functionalized rac-1 were prepared in medium-to-good overall yields (40-90%). Azlactones rac-1 are ideal precursors for the synthesis of optically pure α,α-disubstituted (R)- and (S)-α-amino acids.