161600-01-7 Usage
Uses
Different sources of media describe the Uses of 161600-01-7 differently. You can refer to the following data:
1. Antidiabetic; orally-administered insulin action enhancer to lower the plasma glucose in patients with non-insulin dependent diabetes mellitus (Type II).
2. MCC 555 belongs to the thiazolidinedion class, a group of compounds with anti-diabetic properties. In addition, MCC 555 has been found to induce apoptosis in pancreatic and colorectal cancer cells involving the?Nonsteroidal anti-inflammatory drug (NSAID)-activated gene?(NAG-1). MCC 555 is an agent with anti-diabetic and anti-cancer properties.
Biological Activity
mcc-555, also known as rwj-241947, is a novel peroxisome proliferator–activated receptor γ ligand [1].the pparγ receptors mainly express in adipose tissue, colon and macrophages involved in regulating fatty acid storage and glucose metabolism. it has been identified that pparγ is the major functional receptor for the thiazolidinedione class of insulin-sensitizing drugs. the pparγ receptor is implicated in the processes of adipogenesis and systemic insulin action [2].mcc-555 (5 μmol/l) exhibited an apoptotic activity in human colorectal cancer cells. mcc-555 significantly increased nag-1 expression in a pparγ-independent manner. in hct-116 cells, treatment with mcc-555 induced apoptosis. mcc-555 affected nag-1 mrna stability. mcc-555 treatment induced rapid phosphorylation of erk1/2 [1]. in various solid and hematological tumor cell lines, mcc-555 showed antiproliferative activity against prostate cancer cells, with the strongest effect against the androgen-independent pc-3 prostate cancer cells [2].in male beige/nude/x-linked immunodeficient (bnx) mice, treatment with mcc-555 profoundly suppressed growth of pc-3 prostate cancer xenografts with prominent apoptosis, fibrosis, and inflammatory and giant cell reaction. the experimented mice showed significantly decreased cholesterol [3].
Biochem/physiol Actions
MCC-555 is a thiazolidinedione class anti-diabetic compound. In rodent models, MCC-555 attenuates the development of diabetes, maintains B-cell function and improves insulin sensitivity. The compound MCC-555 also inhibits proliferation of several cancer cell lines and reduces tumor growth in xenograft models.
references
[1] yamaguchi k, lee s h, eling t e, et al. a novel peroxisome proliferator–activated receptor γ ligand, mcc-555, induces apoptosis via posttranscriptional regulation of nag-1 in colorectal cancer cells[j]. molecular cancer therapeutics, 2006, 5(5): 1352-1361.[2] spiegelman b m. ppar-gamma: adipogenic regulator and thiazolidinedione receptor[j]. diabetes, 1998, 47(4): 507-514.[3] kumagai t, ikezoe t, gui d, et al. rwj-241947 (mcc-555), a unique peroxisome proliferator-activated receptor-γ ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/x-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide[j]. clinical cancer research, 2004, 10(4): 1508-1520.
Check Digit Verification of cas no
The CAS Registry Mumber 161600-01-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,6,0 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 161600-01:
(8*1)+(7*6)+(6*1)+(5*6)+(4*0)+(3*0)+(2*0)+(1*1)=87
87 % 10 = 7
So 161600-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H16FNO3S/c22-18-4-2-1-3-16(18)12-26-17-8-7-14-9-13(5-6-15(14)11-17)10-19-20(24)23-21(25)27-19/h1-9,11,19H,10,12H2,(H,23,24,25)
161600-01-7Relevant articles and documents
PREVENTIVE AND/OR REMEDIAL AGENT FOR DISEASE ATTRIBUTABLE TO ARTERIOSCLEROTIC ACTIVITY
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Page/Page column 6, (2008/06/13)
A preventive and/or therapeutic medicament for diseases attributed to arteriosclerotic activity such as ischemic heart diseases and acute coronary arterial syndromes and the like, which contains as an active ingredient a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: A preventive and/or therapeutic agent for diseases based on arteriosclerotic activity which is more potent than known drugs hereinbefore and novel is provided. In the formula, A represents a thiazolidinedione ring and the like; -X- represents -O- or -S-; =Y- represents="N-" or =CR5-; R1 R2, R3, R4 and R5 each independently represent hydrogen and the like; n is an integer of 0 to 3; and the dotted line indicates that said linkage may be a double bond.
Method for preventing and for treating autoimmune disease
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, (2008/06/13)
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.