161605-73-8 Usage
Uses
ZK 200775 is a competitive AMPA/kainate antagonist. Neuronal protection against cerebral ischemia.
Biological Activity
Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [ 3 H]-AMPA (K i = 120 nM) and [ 3 H]-CNQX (K i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC 50 values range from 2.5 to 11 μ M). Inhibits currents induced by AMPA, kainate and NMDA with IC 50 values of 21 nM, 27 nM, and > 1 μ M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 161605-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,6,0 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 161605-73:
(8*1)+(7*6)+(6*1)+(5*6)+(4*0)+(3*5)+(2*7)+(1*3)=118
118 % 10 = 8
So 161605-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H15F3N3O6P/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25)
161605-73-8Relevant articles and documents
Quinoxalinedione derivatives, their production and use in pharmaceutical agents
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, (2008/06/13)
Compounds of formula I are described STR1 in which R 1, R 5, R 6, R 7 and R 8 have the meanings mentioned in the application as well as their production and use in pharmaceutical agents.
