161608-46-4Relevant academic research and scientific papers
3-AMINOAZEPINE COMPOUND AND PHARMACEUTICAL USE THEREOF
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, (2008/06/13)
A 3-aminoazepine compound represented by general formula (I), an optically active isomer thereof, or a pharmaceutically acceptable salt thereof, wherein Ar represents phenyl, etc.; R1 represents hydrogen, alkyl, etc.; R2 and R3 represent each independently hydrogen, alkyl,-CO-R? (wherein R? represents heteroaryl, etc.),-CONH-R? (wherein R? represents phenyl, etc.), etc.; R? represents hydrogen, alkyl, etc.; X represents oxygen or sulfur, provided R? and X may be combined together to form-C(R1?)=N-N= (wherein R1? represents hydrogen, alkyl, etc.). This compound has CCK and gastrin antagonisms and is useful as a remedy for central nervous system diseases such as anxiety and depression and as a preventive or a remedy for pancreatic diseases and gastrointestinal ulcer.
