1616292-69-3Relevant articles and documents
Sophoridine Derivatives Induce Apoptosis and Autophagy to Suppress the Growth of Triple-Negative Breast Cancer through Inhibition of mTOR Signaling
Dai, Linlin,Wang, Luyao,Tan, Cheng,Cai, Jun,Shen, Hongsheng,Zhang, Ting,Zhi, Shuang,Yang, Zibo,Hu, Yunhui,Zhao, Xiumei,Li, Dongdong
, (2021/10/14)
In order to improve the antitumor potency and therapeutic margins of natural product sophoridine, its novel nitrogen mustard carbamate derivatives were designed and synthesized. In screening their in vitro activity, we found all the tested compounds were
Sophoridine amine derivative, preparation method thereof and application
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, (2017/10/07)
The invention relates to a sophoridine amine derivative, a preparation method thereof and an application, in particular to a compound as shown in a formula I, an optical isomer of the compound, a solvate of the compound or pharmaceutically acceptable salt of the compound. The compound is novel in structure and has excellent anti-tumor activity and good inhibitory activity for cancers such as liver cancer, lung adenocarcinoma, breast cancer, stomach cancer, colon cancer, cervical cancer, ovarian cancer, lymphoma, glioma, brain glioma and melanoma.