1616379-75-9

Upstream product

• 1616379-64-6 tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate 
• 1467751-07-0 (R,E)-N-((R)-3,4-bis(tert-butyldimethylsilyloxy)butylidene)-2-methylpropane-2-sulfinamide 
• 503604-05-5 (+)-(R)-methyl 3,4-bis((tert-butyldimethylsilyl)oxy)butanoate 
• 486444-34-2 (+)-(R)-3,4-bis((tert-butyldimethylsilyl)oxy)butanal 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1616379-98-6 (R)-N-((1S,3R)-3,4-bis(tert-butyldimethylsilyloxy)-1-p-tolylbutyl)-2-methylpropane-2-sulfinamide 

Relevant academic research and scientific papers

An efficient method for the preparation of 3-hydroxyl-5-substituted 2-pyrrolidones and application in the divergent synthesis of (-)-preussin and its analogues

An asymmetric method to (S,R)-α-hydroxyl-γ-amino alcohols 12 through a diastereoselective addition of Grignard reagents to β-chiral aldimines 11 is described. Subsequent oxidation/cyclization with Sarett reagent provided a novel approach to lactams 14, a flexible building block whose utility was demonstrated in the divergent synthesis of antifungal agent (-)-preussin 5 and its three analogues 23, 24, 25.