161644-41-3

Upstream product

• 103-04-8 (phenylthio)acetic acid 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 

Downstream Products

• 161644-46-8 tert-butyl (S)-3-<2,2-dimethyl-3-(phenylthioacetyl)oxazolidin-4-yl>-(E)-propenoate 
• 161644-50-4 tert-butyl (6S,7R,7aS)-5,6,7,7a-tetrahydro-3,3-dimethyl-5-oxo-6-phenylthio-1H,3H-pyrrolo<1,2-c>oxazol-7-ylacetate 
• 161644-45-7 ethyl (S)-3-<2,2-dimethyl-3-(phenylthioacetyl)oxazolidin-4-yl>-(E)-propenoate 
• 1025965-41-6 (R)-2,2-Dimethyl-3-(2-phenylsulfanyl-acetyl)-oxazolidine-4-carbaldehyde 
• 161644-44-6 (S)-2,2-dimethyl-3-(phenylthioacetyl)oxazolidine-4-methanol 
• 161644-42-4 methyl (R)-2,2-dimethyl-3-(phenylthioacetyl)oxazolidine-4-carboxylate 

Relevant academic research and scientific papers

SYNTHESIS OF A SIMPLE KAINIC ACID ANALOGUE BY MEANS OF CARBAMOYLMETHYL RADICAL CYCLIZATION

A new approach to (-)-(2S,3R)-2-carboxy-3-pyrrolidineacetic acid (6) starting from D-serine is described.The key step is a radical cyclization of tert-butyl (S)-3-oxazolidin-4-yl>-(E)-propenoate (15b), which gave tert-butyl (6S,7R,7aS)-5,6,7,7a-tetrahydro-3,3-dimethyl-5-oxo-6-phenylthio-1H,3H-pyrrolooxazol-7-ylacetate (16b) in a highly regio- and diastereo-selective manner.The compound (16b) was then coverted into tert-butyl (4R,5S)-5-(tert-butyldimethylsilyloxymethyl)-1-methoxycarbonyl-2-oxopyrrolidin-4-ylacetate (19) by standard chemical manipulations, which has already been transformed to 6.