1616470-69-9Relevant academic research and scientific papers
Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties
Watanabe, Takayoshi,Hoshida, Tomoko,Sakyo, Jun,Kishi, Mariko,Tanabe, Satoshi,Matsuura, Junichi,Akiyama, Shingo,Nakata, Makiko,Tanabe, Yasuaki,Suzuki, Akinobu Z.,Watanabe, Soichiro,Furuta, Toshiaki
, p. 5089 - 5093 (2014)
A nucleobase-caged peptide nucleic acid (PNA) having a (6-bromo-7- methoxycoumarin)-4-ylmethoxycarbonyl (Bmcmoc) caging group was newly synthesized. The Bmcmoc-caged PNAs were photolyzed to produce parent PNAs with a high photochemical efficiency. Introduction of a single Bmcmoc group was sufficient to suppress polymerase chain reaction (PCR) clamping activity and triplex invasion complex formation. Photo-mediated restoration of the PCR clamping activity was also demonstrated.
