1616508-45-2

Basic information

• Product Name: (S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one
• Synonyms: (S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one
• CAS NO: 1616508-45-2
• Molecular Weight: 381.401
• Mol File: 1616508-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one(1616508-45-2)
• EPA Substance Registry System: (S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one(1616508-45-2)

Safety Data

• Hazardous Substances Data: 1616508-45-2(Hazardous Substances Data)

Upstream product

• 1616508-41-8 (4S)-3-(2-fluoropropanoyl)-4-benzyloxazolidin-2-one 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 312583-58-7 (1S,2S)-1,2-bis(2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 879551-04-9 (3R,4R,5R)-3?fluoro?4?hydroxy?5?(hydroxymethyl)?3?methyltetrahydrofuran?2?one 
• 874638-80-9 ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE

A novel process for the preparation of a fluorolactone derivative of the formula (I) and of its acylated derivative of formula (V) wherein R1 stands for a hydroxy protecting group is described. The acylated fluorolactones of formula (V), particularly the benzoyl derivative with R1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.