1616562-90-3Relevant academic research and scientific papers
A facile synthesis of 3-hydroxy-3-(trifluoromethyl)-1H-pyrrol-2(3H)-ones with Br?nsted acid-catalyzed condensation-cyclization reactions of β-enamino esters and ethyl trifluoropyruvate
Pei, Qing-Lan,Cui, Bao-Dong,Han, Wen-Yong,Wu, Zhi-Jun,Zhang, Xiao-Mei,Yuan, Wei-Cheng
, p. 4595 - 4601 (2014/06/23)
A facile synthesis of 3-hydroxy-3-(trifluoromethyl)-1H-pyrrol-2(3H)-ones based on trifluoroacetic acid-catalyzed condensation-cyclization reactions of β-enamino esters and ethyl trifluoropyruvate is described. These reactions afford a series of α-trifluoromethylated γ-lactam compounds in good to excellent yields under mild conditions. A preliminary trial of an asymmetric catalytic version with chiral BINOL-derived phosphoric acid as enantioselective catalyst was conducted and showed promising enantioselectivity of the desired product.
