1616590-44-3

Basic information

• Product Name: C₁₇H₂₄N₂O₅S
• Synonyms: C₁₇H₂₄N₂O₅S
• CAS NO: 1616590-44-3
• Molecular Weight: 368.454
• Mol File: 1616590-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₄N₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₄N₂O₅S(1616590-44-3)
• EPA Substance Registry System: C₁₇H₂₄N₂O₅S(1616590-44-3)

Safety Data

• Hazardous Substances Data: 1616590-44-3(Hazardous Substances Data)

Upstream product

• 66657-42-9 2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl chloride 
• 17994-94-4 methyl 7-aminoheptanoate hydrochloride 

Relevant articles and documents

Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors

Histone deacetylase (HDAC) inhibitions are known to elicit anticancer effects. We designed and synthesized several HDAC inhibitors. Among these compounds, compound 40 exhibited a more than 10-fold stronger inhibitory activity compared with that of suberoylanilide hydroxamic acid (SAHA) against each human HDAC isozyme in vitro (IC50 values of 40: HDAC1, 0.0038 μM; HDAC2, 0.0082 μM; HDAC3, 0.015 μM; HDAC8, 0.0060 μM; HDAC4, 0.058 μM; HDAC9, 0.0052 μM; HDAC6, 0.058 μM). The dose of the administered HDAC inhibitors that contain hydroxamic acid as the zinc-binding group may be reduced by 40. Because the carbostyril subunit is a time-tested structural component of drugs and biologically active compounds, 40 most likely exhibits good absorption, distribution, metabolism, excretion, and toxicity (ADMET). Thus, compound 40 is expected to be a promising therapeutic agent or chemical tool for the investigation of life process.