1616596-31-6

Upstream product

• 1616596-33-8 tert-butyl 2-(2-cyano-4-(1H-tetrazol-1-yl)phenyl)acetate 
• 72115-09-4 5-amino-2-bromo-benzonitrile 
• 1616596-32-7 tert-butyl 2-(4-amino-2-cyanophenyl)acetate 

Relevant academic research and scientific papers

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.